2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel

TRP Channel

Transient receptor potential channels

TRP Channel

Related Products

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Isoform Specific Products:

TRP Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-104061
    AMG8788
    		Antagonist
    AMG8788 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 63.2 nM.
    AMG8788
  • HY-144205
    TRPC5-IN-2
    		Inhibitor
    TRPC5-IN-2 is a potent TRPC5 inhibitor (WO2019055966A2, Compound IO).
    TRPC5-IN-2
  • HY-W002116S
    Methyl syringate-d6
    Methyl syringate-d6 is the deuterium labeled Methyl syringate[1]. Methyl syringate, a chemical marker of asphodel monofloral honey, is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a TRPA1 agonist[2][3][4].
    Methyl syringate-d<sub>6</sub>
  • HY-139006
    N-Oleoyl glutamine
    		Inhibitor
    N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist.
    N-Oleoyl glutamine
  • HY-133168R
    Englerin A (Standard)
    		Activator
    Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload.
    Englerin A (Standard)
  • HY-104062
    AMG9678
    		Antagonist
    AMG9678 is a potent, selective, orally active antagonist of TRPM8 with an IC50 of 31.2 nM.
    AMG9678
  • HY-137459A
    Vocacapsaicin hydrochloride
    		Antagonist
    Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief.
    Vocacapsaicin hydrochloride
  • HY-169824
    TRPML modulator 1
    TRPML modulator 1 (compound A12) is a TRPML modulator that promotes autophagy. TRPML modulator 1 AC50 in the TFEB test is less than 2 mM.
    TRPML modulator 1
  • HY-17386S2
    Rosiglitazone-d4-1
    		Modulator
    Rosiglitazone-d4-1 (BRL 49653-d4-1) is deuterium-labeled Rosiglitazone (HY-17386).
    Rosiglitazone-d<sub>4</sub>-1
  • HY-123245
    Scalaradial
    		Inhibitor
    Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage.
    Scalaradial
  • HY-148751
    TRPV1 activator-1
    		Activator
    TRPV1 activator-1 (compound 8), a capsaicin analog, has an altered neck structure. TRPV1 activator-1 interacts specifically with T551 residue.
    TRPV1 activator-1
  • HY-N12605
    hTRPA1-IN-1
    		Inhibitor
    hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC50 of 2 μM.
    hTRPA1-IN-1
  • HY-148752
    TRPV1 activator-2
    		Activator
    TRPV1 activator-2 (compound 9), a capsaicin head analog, makes specific interactions with channel residues at the lipid-water.
    TRPV1 activator-2
  • HY-145150
    TRPC5-IN-1
    		Inhibitor
    TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor with 50.5 % Inhibition for TRPC5 at 3 μM. TRPC5-IN-1 can be used for the research of chronic kidney disease (CKD).
    TRPC5-IN-1
  • HY-17386S
    Rosiglitazone-d3
    		Modulator
    Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 μM) and an inhibitor of TRPM3[1][2][3][4].
    Rosiglitazone-d<sub>3</sub>
  • HY-117891
    Davasaicin
    Davasaicin (KR 25018), Capsaicin (HY-10448) derivative, is an orally active analgesic agent.
    Davasaicin
  • HY-110145
    MRS 1477
    		Modulator
    MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis.
    MRS 1477
  • HY-110292
    A-425619
    		Antagonist
    A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain.
    A-425619
  • HY-116330AR
    Hyperforin dicyclohexylammonium salt (Standard)
    		Activator
    Hyperforin (dicyclohexylammonium salt) (Standard) is the analytical standard of Hyperforin (dicyclohexylammonium salt). This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin dicyclohexylammonium salt (Standard)
  • HY-113037
    (E/Z)-Farnesyl pyrophosphate
    		Agonist
    (E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis.
    (E/Z)-Farnesyl pyrophosphate
Cat. No. Product Name / Synonyms Application Reactivity
TRP Channel Isoform Comparison

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